ALTERNATIVE PER IL RILEVAMENTO DI CANCEROGENI
“This paper briefly summarizes the theories on the early steps of carcinogenesis and presents alternative detection methods for carcinogens based on genetic toxicology, structure-activity relationships and cell transformation assays.”
“There is evidence that the combination of Salmonella and structural alerts for the DNA-reactive carcinogens, and in vitro cell transformation assays for nongenotoxic carcinogens, permits the identification of a very large proportion of carcinogens”
Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?
Expert Opin Drug Metab Toxicol. 2012 Apr;8(4):407-17