Di 20 composti noti che non causano il cancro nell’uomo, 19 causano il cancro nei topi
“Twenty of these probable non-carcinogens have been tested for rodent carcinogenicity in animal bioassays; 19 were positive and only one was negative, indicating that the specificity of animal bioassays is low”.
[Ennever FK, Noonan TJ, Rosenkranz HS. The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans. Mutagenesis. 1987 Mar;2(2):73-8.]