DIFFERENZE TRA SPECIE E MANCANZA DI PREDITTIVITA’ DEL MODELLO ANIMALE:
NUOVE INTUIZIONI SUL PERCHE’ GLI ESSERI UMANI SONO PIU’ SUSCETTIBILI A CERTE MALATTIE DELLE ALTRE SPECIE:
“it remains largely unknown how patterns of DNA methylation differ between closely related species and whether such differences contribute to species-specific phenotypes.”
“Levels and patterns of DNA methylation vary across individuals within species according to the age and the sex of the individuals.”
“We also found extensive species-level divergence in patterns of DNA methylation and that hundreds of genes exhibit significantly lower levels of promoter methylation in the human brain than in the chimpanzee brain.”
“Our results demonstrate that differential DNA methylation might be an important molecular mechanism driving gene-expression divergence between human and chimpanzee brains and might potentially contribute to the evolution of disease vulnerabilities.”
[Jia Zeng; Dan Geschwind; Brendan G Hunt; Genevieve Konopka; Todd M Preuss; Soojin V Yi. Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. American journal of human genetics 2012;91(3):455-65.