Mancanza di predittività del modello animale negli studi di cancerogenicità

Mancanza di predittività del modello animale negli studi di cancerogenicità:
“However, several investigations have revealed animal carcinogenicity data to be lacking in human predictivity.”

“The likely causes of the poor human predictivity of rodent carcinogenicity bioassays include:
1) the profound discordance of bioassay results between rodent species, strains and genders, and further, between rodents and human beings;
2) the variable, yet substantial, stresses caused by handling and restraint, and the stressful routes of administration common to carcinogenicity bioassays, and their effects on hormonal regulation, immune status and predisposition to carcinogenesis;
3) differences in rates of absorption and transport mechanisms between test routes of administration and other important human routes of exposure;
4) the considerable variability of organ systems in response to carcinogenic insults, both between and within species; and
5) the predisposition of chronic high dose bioassays toward false positive results, due to the overwhelming of physiological defences, and the unnatural elevation of cell division rates during ad libitum feeding studies. Such factors render profoundly difficult any attempts to accurately extrapolate human carcinogenic hazards from animal data.”

http://www.frame.org.uk/dynamic_files/knight_2.pdf
(full text)

qui l’abstract su pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16522148

[Knight A, Bailey J, Balcombe J. Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans. Altern Lab Anim. 2006 Feb;34(1):29-38.]

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