Modello animale di sepsi

“Animal models of sepsis have the potential to cause substantial suffering, and many of them have been poorly representative of the human syndrome. However, a number of non-animal approaches, including in vitro, in silico and clinical studies, show promise for addressing this situation.”

Sui modelli animali:
“Poor predictors of the clinical picture (species differences)
Artificially induced sepsis
High cost
Genetically homogeneous animals unlike the human population”

[Chris Langley, Chris Brock, Gerard Brouwer, Alun Brown, Lucie Clapp, Jon Cohen, Tom Evans, Carol Newman, Samantha Orr, Barry Phillips, Andy Rhodes, Nigel Webster and Karl Wooldridge – Opportunities to Replace the Use of Animals in Sepsis
Research – ATLA 33, 641–648, 2005]
[http://www.drhadwentrust.org/downloads/publications/FoASepsisWorkshopReport2006.pdf]

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