IL PRIMO METODO ALTERNATIVO VALIDATO DA UN’EVIDENZA RETROSPETTIVA NEL RIMPIAZZO DEL DRAIZE TEST
Il Cytosensor Microphysiometer doveva rimpiazzare il Draize Test, ma il risultato fu inizialmente inconcludente, dato che si confrontò il suo risultato con quello del Draize test stesso, finchè non fu validato grazie a meta-analisi retrospettive.
The results for CM were inconclusive as were those from other tests evaluated as stand-alone methods to fully replace the animal test. In 2002, the European Centre for the Validation of Alternative Methods (ECVAM) started applying concepts from evidence-based medicine, and opened validation to retrospective meta-analysis. This activity was done in collaboration with US counterpart ICCVAM/NICEATM, and the European Cosmetics Association, Colipa. After a new, comprehensive evaluation of the prior available data, the ECVAM scientific advisory committee (ESAC) has recently accepted the CM as capable of identifying non-irritants for testing limited to water-soluble surfactants and water-soluble surfactant-containing mixtures.
Hartung T, Bruner L, Curren R, Eskes C, Goldberg A, McNamee P, Scott L, Zuang V.
First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.