La risposta genomica dei modelli murini mima MISERAMENTE i disturbi infiammatori umani

Secondo un nuovo studio pubblicato su “PNAS” (“Proceedings of the National Academy of Sciences of the United States of America”), la risposta genomica dei modelli murini mima MISERAMENTE i disturbi infiammatori umani.

I risultati della sperimentazione sui topi, infatti, non possono essere trasferiti all’uomo per diversi tipi di patologie (sepsi, traumi, sindrome da distress respiratorio, endotossiemia e ustioni).

Abstract:

“A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Among genes changed significantly in humans, the murine orthologs are close to random in matching their human counterparts (e.g., R2 between 0.0 and 0.1). In addition to improvements in the current animal model systems, our study supports higher priority for translational medical research to focus on the more complex human conditions rather than relying on mouse models to study human inflammatory diseases.”

FULL TEXT: http://www.pnas.org/content/early/2013/02/07/1222878110.full.pdf+html

 

[Junhee Seok, H. Shaw Warren, Alex G. Cuenca, Michael N. Mindrinos, Henry V. Baker, Weihong Xu, Daniel R. Richards, Grace P. McDonald-Smith, Hong Gao, Laura Hennessy, Celeste C. Finnerty, Cecilia M. López, Shari Honari, Ernest E. Moore, Joseph P. Minei, Joseph Cuschieri, Paul E. Bankey, Jeffrey L. Johnson, Jason Sperry, Avery B. Nathens, Timothy R. Billiar, Michael A. West, Marc G. Jeschke, Matthew B. Klein, Richard L. Gamelli, Nicole S. Gibran, Bernard H. Brownstein, Carol Miller-Graziano, Steve E. Calvano, Philip H. Mason, J. Perren Cobb, Laurence G. Rahme, Stephen F. Lowry, Ronald V. Maier, Lyle L. Moldawer, David N. Herndon, Ronald W. Davis, Wenzhong Xiao, Ronald G. Tompkins, and the Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Genomic responses in mouse models poorly mimic human inflammatory diseases

PNAS 2013 ; published ahead of print February 11, 2013, doi:10.1073/pnas.1222878110]

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