Modelli di cocoltura 3D per studiare crescita, progressione e metastasi del cancro della prostata all’osso

[Wang R, Xu J, Juliette L, Castilleja A, Love J, Sung SY, Zhau HE, Goodwin TJ, Chung LW. Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone. Semin Cancer Biol. 2005 Oct;15(5):353-64.]

Abstract:

Cancer-stromal interaction results in the co-evolution of both the cancer cells and the surrounding host stromal cells. As a consequence of this interaction, cancer cells acquire increased malignant potential and stromal cells become more inductive. In this review we suggest that cancer-stromal interaction can best be investigated by three-dimensional (3D) co-culture models with the results validated by clinical specimens. We showed that 3D culture promoted bone formation in vitro, and explored for the first time, with the help of the astronauts of the Space Shuttle Columbia, the co-culture of human prostate cancer and bone cells to further understand the interactions between these cells. Continued exploration of cancer growth under 3D conditions will rapidly lead to new discoveries and ultimately to improvements in the treatment of men with hormonal refractory prostate cancer.

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2 risposte a “Modelli di cocoltura 3D per studiare crescita, progressione e metastasi del cancro della prostata all’osso

  1. La prossima volta che c’è un confronto con Garattini alla Rai non potete andarci voi??Per favore!!!!Lo avreste zittito in un secondo!!!
    Ottimo lavoro!!!!Siete strepitosi, in che modo vi si può aiutare?

    Mi piace

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